We have a lot of removal available to us, and it is uncaring of whether creatures have indestructible, or hexproof.
To the Slaughter: Opponents have this hard choice if they are running a more midrangey deck, it just gets worse if we are able to get delirium online. This piece of removal gets around creatures that happen to be hexproof, namely Dragonlord Ojutai, or even Elusive Tormenter, if people start to realize the potential of that card.
Declaration in Stone: Going to be the most played removal spell of standard, I think. It has been great for dealing with Ulamog, or wide token strategies, like lots of zombies from Rise from the Tides.
Grasp of Darkness: Targeted removal of some of the lightning bolt resilient creatures, like Thing in the Ice, Thought-Knot Seer, etc... and again, it doesn't matter if they're indestructible.
Languish: Sometimes a mass removal is necessary to pretty much wipe the board of smaller creatures. What's nice is that it doesn't kill the creatures we care more about on our side. Linvala and Tithes can emerge unscathed from a Languish.
Ruinous Path: Just a good targeted removal for planeswalkers. It can be used on creatures too, but it's better used for those pesky planeswalkers. (Looking at you, Jace). If you have a couple of sorcery/instant cards in the graveyard, you can even Dark Petition it up, if necessary.
Anguished Unmaking: We need some way to deal with Enchantments, and Artifacts that we don't want running amok on the field. The loss of life hurts, and is one of the biggest sources of hemorrhaging life in this deck, but losing 3 life can be necessary in certain situations.